Oocyte_Activation

total fertilization failure still occurs in 2% to 3% of ICSI cycles

 

reveals fertilization failure after ICSI may be explained by defects in oocyte, sperm, or the ICSI procedure

 

Oocyte immaturity or inherited genetic defects may account for failed fertilization related to oocyte factors

 

Expulsion of the injected sperm from the oocytes accounts for up to 20% of unfertilized post-ICSI oocytes.

 

Viability, abnormal chromatin status, inability of sperm nucleus to decondense, or inability of sperm to activate oocytes are sperm defects that may account for failed fertilization after ICSI

 

analysis of failed fertilized oocytes after ICSI has revealed that more than 80% of unfertilized oocytes are arrested at the metaphase II (MII) stage, possibly due to failed oocyte activation

 

a variety of studies have tried to overcome fertilization failure through various methods of artificially activating oocytes after ICSI, including chemical and electrical oocyte activation.

 

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